Endocrine Abstracts

Mice with targeted deletion of GH receptor (GHRKO mice) are GH resistant, small, hypoinsulinemic, very sensitive to insulin and remarkably long-lived. We have previously reported that these animals failed to respond to calorie restriction (CR) by additional increase in insulin sensitivity or extension of longevity. Because GHRKO mice are characterized by increased adiposity and adiposity is normally associated with insulin resistance rather than sensitivity, we hypothesized th...

Introduction: Long-lived mice with targeted disruption of the GHRH gene (GHRH knockout; GHRHKO) constitute a unique animal model of altered somatotrophic signaling and are characterized by reduced body mass and size, low plasma IGF1 and enhanced insulin sensitivity. These features are also observed in long-lived GH receptor knockout (GHRKO) mice, characterized by increased visceral obesity that usually promotes insulin resistance. GHRKO mice have also increased subcutaneous fa...

GH receptor knockout (GHRKO) mice were produced by a targeted disruption of the GH receptor (Ghr) gene. These long-lived mice, which are GH resistant, are characterized by a greatly reduced plasma levels of IGF1 and insulin and have enhanced insulin sensitivity (these effects resemble the characteristics of animals subjected to caloric restriction (CR), which is well known experimental model to delay aging and increase lifespan).Apoptosis, or programmed ...